Age and stage at diagnosis: a hospital series of 11 women with intellectual disability and breast carcinoma

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SATGÉ, Daniel, SAULEAU, Eric-Andre, JACOT, William, RAFFI, Fernand, AZÉMA, Bernard, BOUYAT, Jean-Claude et EL HAGE ASSAF, Nicolas, 2014. Age and stage at diagnosis: a hospital series of 11 women with intellectual disability and breast carcinoma. BMC Cancer [en ligne]. 2014. Vol. 14. [Consultésans date]. DOI 10.1186/1471-2407-14-150. Consulté de : https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-1501. .
Accès libre Peer reviewed
Version finale publiée (post-print éditeur)
Paternité [CC] [BY]
Auteurs Daniel Satgé
Eric-Andre Sauleau
William Jacot
Fernand Raffi
Bernard Azéma
Jean-Claude Bouyat
Nicolas El Hage Assaf
Unité de recherche du site Progression tumorale et microenvironnement. Approches translationnelles et épidémiologie - PTM - EA3430
Langue

en
Volume

14
Date de première publication

2014
Date de parution

2014
ISSN

1471-2407
Titre de la source (revue, livre…)

BMC Cancer
Résumé

BACKGROUND: Breast cancer has been poorly studied in women with intellectual disability (ID), which makes designing a policy for screening the nearly 70 million women with ID in the world difficult. As no data is available in the literature, we
Show moreBACKGROUND: Breast cancer has been poorly studied in women with intellectual disability (ID), which makes designing a policy for screening the nearly 70 million women with ID in the world difficult. As no data is available in the literature, we evaluated breast cancer at diagnosis in women with ID. METHODS: Women with ID were searched retrospectively among all women treated for invasive breast cancer in a single hospital over 18 years. Age at diagnosis was compared among the whole group of women. Tumor size, lymph node involvement, SBR grade, TNM classification, and AJCC stage were compared to controls matched for age and period of diagnosis using conditional logistic regression. RESULTS: Among 484 women with invasive breast cancer, 11 had ID. The mean age at diagnosis was 55.6 years in women with ID and 62.4 years in the other women. The mean tumor size in women with ID was 3.53 cm, compared to 1.80 cm in 44 random controls from among the 473 women without ID. Lymph node involvement was observed in 9 of the 11 women with ID compared to 12 of the controls (OR = 11.53, p = 0.002), and metastases were found in 3 of the 11 women with ID compared to 1 of the 44 controls (OR = 12.00, p = 0.031). The AJCC stage was higher in women with ID compared to controls (OR = 3.19, p = 0.010). CONCLUSIONS: Women with ID presented at an earlier age with tumors of a higher AJCC stage than controls despite no significant differences in tumor grade and histological type. Thus, delayed diagnosis may be responsible for the differences between disabled and non-disabled women.
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DOI 10.1186/1471-2407-14-150
Éditeur

BioMed Central
URL éditeur https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-150
Type de publication

journal article
Type de publication

ACL
Domaine

Aucun
Fonction

aut
Audience

International
URL https://univoak.eu/islandora/object/islandora:53957