Absorption, disposition, metabolism, and excretion of [3-(14)c]caffeic Acid in rats

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OMAR, M. H., MULLEN, W., STALMACH, A., AUGER, Cyril, ROUANET, J. M., TEISSEDRE, P. L., CALDWELL, S. T., HARTLEY, R. C. et CROZIER, A., 2012. Absorption, disposition, metabolism, and excretion of [3-(14)c]caffeic Acid in rats. Journal of Agricultural and Food Chemistry [en ligne]. 2012. Vol. 60, n° 20pp. 5205-5214. [Consultésans date]. DOI 10.1021/jf3001185. Consulté de : http://www.ncbi.nlm.nih.gov/pubmed/22480330
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Auteurs M Omar
W Mullen
A Stalmach
Cyril Auger
J Rouanet
P Teissedre
S Caldwell
R Hartley
A Crozier
Unité de recherche du site Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213
Langue

en
Volume

60
Numéro

20
Page de début

5205
Page de fin

5214
Date de première publication

2012
ISSN

1520-5118
Titre de la source (revue, livre…)

Journal of Agricultural and Food Chemistry
Résumé

Male Sprague-Dawley rats ingested 140 x 10(6) dpm of [3-(14)C]trans-caffeic acid, and over the ensuing 72 h period, body tissues, plasma, urine, and feces were collected and the overall levels of radioactivity determined. Where sufficient
Show moreMale Sprague-Dawley rats ingested 140 x 10(6) dpm of [3-(14)C]trans-caffeic acid, and over the ensuing 72 h period, body tissues, plasma, urine, and feces were collected and the overall levels of radioactivity determined. Where sufficient radioactivity had accumulated, samples were analyzed by HPLC with online radioactivity and tandem mass spectrometric detection. Nine labeled compounds were identified, the substrate and its cis isomer, 3'-O- and 4'-O-sulfates and glucuronides of caffeic acid, 4'-O-sulfates and glucuronides of ferulic acid, and isoferulic acid-4'-O-sulfate. Four unidentified metabolites were also detected. After passing down the gastrointestinal tract, the majority of the radiolabeled metabolites were excreted in urine with minimal accumulation in plasma. Only relatively small amounts of an unidentified (14)C-labeled metabolite were expelled in feces. There was little or no accumulation of radioactivity in body tissues, including the brain. The overall recovery of radioactivity 72 h after ingestion of [3-(14)C]caffeic acid was approximately 80% of intake.
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DOI 10.1021/jf3001185
Éditeur

American Chemical Society
URL éditeur http://www.ncbi.nlm.nih.gov/pubmed/22480330
Type de publication

journal article
Type de publication

ACL
Fonction

ctb
aut
URL https://univoak.eu/islandora/object/islandora:56328