Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors

KUMMERLE, A. E., SCHMITT, Martine, CARDOZO, S. V., LUGNIER, Claire, VILLA, Pascal, LOPES, A. B., ROMEIRO, N. C., JUSTINIANO, Hélène, MARTINS, M. A., FRAGA, C. A., BOURGUIGNON, Jean-Jacques J. et BARREIRO, E. J., 2012. Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors. Journal of Medicinal Chemistry [en ligne]. 14 août 2012. Vol. 55, n° 17pp. 7525-7545. [Consultésans date]. DOI 10.1021/jm300514y. Consulté de : https://pubs.acs.org/doi/10.1021/jm300514y1. .