Air-Spun PLA Nanofibers Modified with Reductively Sheddable Hydrophilic Surfaces for Vascular Tissue Engineering : Synthesis and Surface Modification

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KO, Na Re, SABBATIER, Gad, CUNNINGHAM, Alexander, LAROCHE, Gaetan et OH, Jung Kwon, 2013. Air-Spun PLA Nanofibers Modified with Reductively Sheddable Hydrophilic Surfaces for Vascular Tissue Engineering : Synthesis and Surface Modification. Macromolecular Rapid Communications [en ligne]. 23 septembre 2013. Vol. 35, n° 4pp. 447-453. [Consultésans date]. DOI 10.1002/marc.201300609. Consulté de : http://onlinelibrary.wiley.com/doi/10.1002/marc.201300609/abstract;jsessionid=C5DA79266A5703D7B06D02BF78D30C7D.f04t01?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+26th+November+2016+from+07%3A00-11%3A00+GMT+%2F+02%3A00-06%3A00+EST+%2F+15%3A00-19%3A00+SGT+for+essential+maintenance.++Apologies+for+the+inconvenience.
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Auteurs Na Ko
Gad Sabbatier
Alexander Cunningham
Gaetan Laroche
Jung Oh
Unité de recherche du site Laboratoire de Physique et Mécanique Textiles - LPMT - EA4365
Langue

en
Volume

35
Numéro

4
Page de début

447
Page de fin

453
Date de première publication

2013-09-23
ISSN

1521-3927
Titre de la source (revue, livre…)

Macromolecular Rapid Communications
Résumé

Polylactide (PLA) is a class of promising biomaterials that hold great promise for various biological and biomedical applications, particularly in the field of vascular tissue engineering where it can be used as a fibrous mesh to coat the inside of
Show morePolylactide (PLA) is a class of promising biomaterials that hold great promise for various biological and biomedical applications, particularly in the field of vascular tissue engineering where it can be used as a fibrous mesh to coat the inside of vascular prostheses. However, its hydrophobic surface providing nonspecific interactions and its limited ability to further modifications are challenges that need to be overcome. Here, the development of new air-spun PLA nanofibers modified with hydrophilic surfaces exhibiting reduction response is reported. Surface-initiated atom transfer radical polymerization allows for grafting pendant oligo(ethylene oxide)-containing polymethacrylate (POEOMA) from PLA air-spun fibers labeled with disulfide linkages. The resulting PLA-ss-POEOMA fibers exhibit enhanced thermal stability and improved surface properties, as well as thiol-responsive shedding of hydrophilic POEOMA by the cleavage of its disulfide linkages in response to reductive reactions, thus tuning the surface properties.
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DOI 10.1002/marc.201300609
Éditeur

Wiley-VCH Verlag
URL éditeur http://onlinelibrary.wiley.com/doi/10.1002/marc.201300609/abstract;jsessionid=C5DA79266A5703D7B06D02BF78D30C7D.f04t01?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+26th+November+2016+from+07%3A00-11%3A00+GMT+%2F+02%3A00-06%3A00+EST+%2F+15%3A00-19%3A00+SGT+for+essential+maintenance.++Apologies+for+the+inconvenience.
Type de publication

journal article
Type de publication

ACL
Fonction

ctb
aut
URL https://univoak.eu/islandora/object/islandora:56701