Ammonium and guanidinium dendron-carbon nanotubes by amidation and click chemistry and their use for siRNA delivery.

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BATTIGELLI, Alessia, WANG, Julie Tzu-Wen, RUSSIER, Julie, DA ROS, Tatiana, KOSTARELOS, Kostas, AL-JAMAL, Khuloud T, PRATO, Maurizio et BIANCO, Alberto, 2013. Ammonium and guanidinium dendron-carbon nanotubes by amidation and click chemistry and their use for siRNA delivery. Small (Weinheim an der Bergstrasse, Germany) [en ligne]. 6 mai 2013. Vol. 9, n° 21pp. 3610-9. [Consulté 6 mai 2013]. DOI 10.1002/smll.201300264. Consulté de : https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2013002641. journal article. 2. research support, non-u.s. gov't. 3. 2013 Nov 11. 4. 2013 05 06. 5. . 6. imported. 7. .
Accès libre Peer reviewed
Version finale publiée (post-print éditeur)
Paternité - Pas d'utilisation commerciale - Pas de modification [CC] [BY] [NC] [ND]
Auteurs Alessia Battigelli
Julie Tzu-Wen Wang
Julie Russier
Tatiana Da Ros
Kostas Kostarelos
Khuloud T Al-Jamal
Maurizio Prato
Alberto Bianco
Unité de recherche du site IBMC - Immunopathologie et chimie thérapeutique - ICT - UPR3572
Langue

en
Volume

9
Numéro

21
Page de début

3610
Page de fin

3619
Date de première publication

2013-05-06
Date de parution

2013-11-11
Titre de la source (revue, livre…)

Small (Weinheim an der Bergstrasse, Germany)
Résumé

A series of multi-walled carbon nanotube (MWCNT) conjugates is described, functionalized with different dendrons bearing positive charges at their termini (i.e. ammonium or guanidinium groups). The dendrimeric units are anchored to the nanotube Show moreA series of multi-walled carbon nanotube (MWCNT) conjugates is described, functionalized with different dendrons bearing positive charges at their termini (i.e. ammonium or guanidinium groups). The dendrimeric units are anchored to the nanotube scaffolds using two orthogonal synthetic approaches, amidation and click reactions. The final nanohybrids are characterized by complementary analytical techniques, while their ability to interact with siRNA is investigated by means of agarose gel electrophoresis. The demonstration of the cell uptake capacity, the low cytotoxicity, and the ability of these cationic conjugates to silence cytotoxic genes suggests them to be promising carriers for genetic material. Show less
DOI 10.1002/smll.201300264
Éditeur

Wiley
URL éditeur https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201300264
Titre abrégé de la source

Small
Type de publication

journal article
Type de publication

ACL
Topic

Chimie/Chimie thérapeutique
chemistry
administration & dosage
genetics
Mots-clés

RNA delivery
carbon nanotubes
cationic dendrons
gene therapy
siRNA
Nom de la collaboration

BB/J008656/1
PMID 23650276
Fonction

aut
Identifiant idREF 175945136
111191211
Audience

International
Envoyer vers HAL

5
URL https://univoak.eu/islandora/object/islandora:70937