Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions.

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MATHIAN, Alexis, PARIZOT, Christophe, DORGHAM, Karim, TRAD, Salim, ARNAUD, Laurent, LARSEN, Martin, MIYARA, Makoto, HIÉ, Miguel, PIETTE, Jean-Charles, FRANCES, Camille, YSSEL, Hans, AMOURA, Zahir et GOROCHOV, Guy, 2012. Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions. Annals of the Rheumatic Diseases. juillet 2012. Vol. 71, n° 7pp. 1227-34. DOI 10.1136/annrheumdis-2011-200709. 1. journal article. 2. research support, non-u.s. gov't. 3. 2012 Jul. 4. . 5. imported.
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Auteurs Alexis Mathian
Christophe Parizot
Karim Dorgham
Salim Trad
Laurent Arnaud
Martin Larsen
Makoto Miyara
Miguel Hié
Jean-Charles Piette
Camille Frances
Hans Yssel
Zahir Amoura
Guy Gorochov
Langue

en
Volume

71
Numéro

7
Date de première publication

2012-07
Titre de la source (revue, livre…)

Annals of the Rheumatic Diseases
Résumé

Transforming growth factor-β is considered to play a key role in the process of fibrosis in systemic sclerosis (SSc) and in the development of regulatory T cells (Treg) and pro-inflammatory Th17 T cells producing interleukin 17 (IL-17) and IL-22. The Show moreTransforming growth factor-β is considered to play a key role in the process of fibrosis in systemic sclerosis (SSc) and in the development of regulatory T cells (Treg) and pro-inflammatory Th17 T cells producing interleukin 17 (IL-17) and IL-22. The authors therefore postulated that SSc could be characterised by a marked Treg/Th17 imbalance. Previous works did not distinguish between the different subsets of Treg and the non-regulatory FoxP3(+) cells leading to inconsistent results. Show less
DOI 10.1136/annrheumdis-2011-200709
Titre abrégé de la source

Ann Rheum Dis
Type de publication

journal article
Type de publication

ACL
Domaine

Aucun
PMID 22696687
Unité de recherche extérieure au site

(INSERM) UMR-S 945, Paris, France
AP-HP, Groupement Hospitalier Pitié-Salpêtrièr, Department of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), CHU Pitié-Salpêtrière, Paris, France
Université Pierre et Marie Curie, Univ Paris 6, Pole 3m, Paris, France
AP-HP, Groupement Hospitalier Pitié-Salpêtrière, Department of Internal Medicine 2, Paris, France
Audience

Non spécifiée
URL https://univoak.eu/islandora/object/islandora:89684