Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor

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PARKULA, Vitaliy, BERTO, Marcello, DIACCI, Chiara, PATRAHAU, Bianca, DI LAURO, Michele, KOVTUN, Alessandro, LISCIO, Andrea, SENSI, Matteo, SAMORI, Paolo, GRECO, Pierpaolo, BORTOLOTTI, Carlo A. et BISCARINI, Fabio, 2020. Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor. Analytical Chemistry. 2 juin 2020. Vol. 92, n° 13pp. 9330-9337. DOI 10.1021/acs.analchem.0c01655.
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Version acceptée pour publication (post-print auteur)
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Auteurs Vitaliy Parkula
Marcello Berto
Chiara Diacci
Bianca Patrahau
Michele Di Lauro
Alessandro Kovtun
Andrea Liscio
Matteo Sensi
Paolo Samori
Pierpaolo Greco
Carlo A. Bortolotti
Fabio Biscarini
Unité de recherche du site Institut de Science et d'Ingénierie Supramoléculaires - ISIS - UMR7006
Langue

en
Volume

92
Numéro

13
Page de début

9330
Page de fin

9337
Date de première publication

2020-06-02
ISSN

0003-2700
1520-6882
Titre de la source (revue, livre…)

Analytical Chemistry
Résumé

Electrolyte gated organic transistors can operate as powerful ultrasensitive biosensors, and efforts are currently devoted to devising strategies for reducing the contribution of hardly avoidable, nonspecific interactions to their response, to Show moreElectrolyte gated organic transistors can operate as powerful ultrasensitive biosensors, and efforts are currently devoted to devising strategies for reducing the contribution of hardly avoidable, nonspecific interactions to their response, to ultimately harness selectivity in the detection process. We report a novel lab-on-a-chip device integrating a multigate electrolyte gated organic field-effect transistor (EGOFET) with a 6.5 μL microfluidics set up capable to provide an assessment of both the response reproducibility, by enabling measurement in triplicate, and of the device selectivity through the presence of an internal reference electrode. As proof-of-concept, we demonstrate the efficient operation of our pentacene based EGOFET sensing platform through the quantification of tumor necrosis factor alpha with a detection limit as low as 3 pM. Sensing of inflammatory cytokines, which also include TNFα, is of the outmost importance for monitoring a large number of diseases. The multiplexable organic electronic lab-on-chip provides a statistically solid, reliable, and selective response on microliters sample volumes on the minutes time scale, thus matching the relevant key-performance indicators required in point-of-care diagnostics. Show less
DOI 10.1021/acs.analchem.0c01655
Titre abrégé de la source

Anal. Chem.
Type de publication

ACL
Topic

Chimie/Matériaux
Unité de recherche extérieure au site

Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy
Istituto per la Sintesi Organica e la Fotoreattività, CNR, Via Piero Gobetti, 101, 40129 Bologna, Italy
Istituto per la Microelettronica e Microsistemi, CNR, Via del Fosso del Cavaliere, 100, 00133 Roma, Italy
Scriba Nanotecnologie S.r.l., Via di Corticella 1838, 40128 Bologna, Italy
Fonction

aut
Identifiant idREF 109288335
Audience

International
Envoyer vers HAL

5
URL https://univoak.eu/islandora/object/islandora:97304