Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor
| Accès restreint (01-12-2020) Peer reviewed | |
|---|---|
| Version acceptée pour publication (post-print auteur) | |
Paternité - Pas d'utilisation commerciale [CC] [BY] [NC]  |
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| Auteurs |
Vitaliy Parkula Marcello Berto Chiara Diacci Bianca Patrahau Michele Di Lauro Alessandro Kovtun Andrea Liscio Matteo Sensi Paolo Samorì Pierpaolo Greco Carlo A. Bortolotti Fabio Biscarini |
| Unité de recherche du site |
Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy Istituto per la Sintesi Organica e la Fotoreattività, CNR, Via Piero Gobetti, 101, 40129 Bologna, Italy Istituto per la Microelettronica e Microsistemi, CNR, Via del Fosso del Cavaliere, 100, 00133 Roma, Italy University of Strasbourg, CNRS, ISIS UMR 70068, Alleé Gaspard Monge, 67000 Strasbourg, France Scriba Nanotecnologie S.r.l., Via di Corticella 1838, 40128 Bologna, Italy |
| Langue |
en |
| Volume |
92 |
| Numéro |
13 |
| Page de début |
9330 |
| Page de fin |
9337 |
| Date de première publication |
2020-06-02 |
| ISSN |
0003-2700 |
| Titre de la source (revue, livre…) |
Analytical Chemistry |
| Résumé |
Electrolyte gated organic transistors can operate as powerful ultrasensitive biosensors, and efforts are currently devoted to devising strategies for reducing the contribution of hardly avoidable, nonspecific interactions to their response, to Show moreElectrolyte gated organic transistors can operate as powerful ultrasensitive biosensors, and efforts are currently devoted to devising strategies for reducing the contribution of hardly avoidable, nonspecific interactions to their response, to ultimately harness selectivity in the detection process. We report a novel lab-on-a-chip device integrating a multigate electrolyte gated organic field-effect transistor (EGOFET) with a 6.5 μL microfluidics set up capable to provide an assessment of both the response reproducibility, by enabling measurement in triplicate, and of the device selectivity through the presence of an internal reference electrode. As proof-of-concept, we demonstrate the efficient operation of our pentacene based EGOFET sensing platform through the quantification of tumor necrosis factor alpha with a detection limit as low as 3 pM. Sensing of inflammatory cytokines, which also include TNFα, is of the outmost importance for monitoring a large number of diseases. The multiplexable organic electronic lab-on-chip provides a statistically solid, reliable, and selective response on microliters sample volumes on the minutes time scale, thus matching the relevant key-performance indicators required in point-of-care diagnostics. Show less |
| DOI | 10.1021/acs.analchem.0c01655 |
| Titre abrégé de la source |
Anal. Chem. |
| Type de publication |
ACL |
| Domaine |
Chimie/Matériaux |
| Audience |
International |
| Envoyer vers HAL |
1 |
| URL | https://univoak.eu/islandora/object/islandora:97304 |