Laboratoire d'Innovation Thérapeutique - LIT - UMR7200

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A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis
Development of Dipeptidic hGPR54 Agonists.
Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging
Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulation
Methylation of imidazoline related compounds leads to loss of alpha(2)-adrenoceptor affinity. Synthesis and biological evaluation of selective I(1) imidazoline receptor ligands
Novel amino-pyrroline derivatives, and use thereof in the prevention and/or treatment of metabolic syndrome
Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells
Rapid and scalable synthesis of innovative unnatural α,β or γ-amino acids functionalized with tertiary amines on their side-chains.
Red fluorescent turn-on ligands for imaging and quantifying G protein-coupled receptors in living cells
Squaraine as a bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging
Synthesis and biological evaluation of 2-aryliminopyrrolidines as selective ligands for I1 imidazoline receptors: discovery of new sympatho-inhibitory hypotensive agents with potential beneficial effects in metabolic syndrome