Laboratoire d'Innovation Thérapeutique - LIT - UMR7200

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A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis
A strategy to discover decoy chemokine ligands with an anti-inflammatory activity
Aerobic Copper-Mediated Domino Three-Component Approach to 2-Aminobenzothiazole Derivatives
An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in mice
Bioactive Flavaglines: Synthesis and Pharmacology
Composition contenant au moins un inhibiteur de certaines chimiokines, son procédé d’obtention et son utilisation en dermocosmétique pharmaceutique
Contrôle qualité des chimiothèques. [= Quality control of chemical libraries]
Deciphering of the mechanism of the anti-asthmatic action of the CXCL12 neutraligand, chalcone 4
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors
Development of Dipeptidic hGPR54 Agonists.
Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors
Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1
Fluorescent dyes and dye precursors
Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging
Inhibitors of the interaction between a protein belonging to GPRASP protein family and a protein belonging to GPCR protein family and their use as drugs
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments
Les neutraligands à l'assaut des chimiokines
Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulation

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