Laboratoire d'Innovation Thérapeutique - LIT - UMR7200

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Aerobic Copper-Mediated Domino Three-Component Approach to 2-Aminobenzothiazole Derivatives
CASTANHEIRO, Thomas, SUFFERT, Jean, GULEA, Mihaela et DONNARD, Morgan, 2016. Aerobic Copper-Mediated Domino Three-Component Approach to 2-Aminobenzothiazole Derivatives. Organic Letters [en ligne]. 18 mai 2016. Vol. 18, n° 11pp. 2588-2591. [Consultésans date]. DOI 10.1021/acs.orglett.6b00967. Consulté de : https://pubs.acs.org/doi/10.1021/acs.orglett.6b009671. .
An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in mice
DAUBEUF, François, HACHET-HAAS, Muriel, GIZZI, Patrick, GASPARIK, Vincent, BONNET, Dominique, UTARD, Valérie, HIBERT, Marcel, FROSSARD, Nelly et GALZI, Jean-Luc ., 2013. An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in mice. Journal of Biological Chemistry [en ligne]. 28 février 2013. Vol. 288, n° 17pp. 11865-11876. [Consultésans date]. DOI 10.1074/jbc.M112.449348. Consulté de : http://www.jbc.org/content/288/17/118651. .
Bioactive Flavaglines: Synthesis and Pharmacology
BASMADJIAN, Christine, ZHAO, Qian, DE GRAMONT, Armand, SEROVA, Maria, FAIVRE, Sandrine, RAYMOND, Eric, VAGNER, Stephan, ROBERT, Caroline, NEBIGIL, Canan, DÉSAUBRY, Laurent et BRAHMACHARI, Goutam, 2015. Bioactive Flavaglines: Synthesis and Pharmacology. Bioactive Natural Products: Chemistry and Biology [en ligne]. 24 juillet 2015. [Consultésans date]. DOI 10.1002/9783527684403.ch7. Consulté de : https://onlinelibrary.wiley.com/doi/10.1002/9783527684403.ch71. .
Composition contenant au moins un inhibiteur de certaines chimiokines, son procédé d’obtention et son utilisation en dermocosmétique pharmaceutique
BERNARD, Philippe, ABBOUD, Dayana, GALZI, Jean-Luc, FROSSARD, Nelly, PILLARD, Christelle et DO, Quoc Tuan, 2016. Composition contenant au moins un inhibiteur de certaines chimiokines, son procédé d’obtention et son utilisation en dermocosmétique pharmaceutique. [en ligne]. 25 mars 2016. [Consultésans date]. Consulté de : https://bases-brevets.inpi.fr/fr/document/FR3026011.html?s=1528277432184&p=5&cHash=b7214024617a485e8dcb90cbbd1d6bfa1. .
Contrôle qualité des chimiothèques. [= Quality control of chemical libraries]
GALZI, Jean-Luc ., RUGGIU, Fiorella, GIZZI, Patrick et DIDIER, Bruno, 2015. Contrôle qualité des chimiothèques. [= Quality control of chemical libraries]. médecine/sciences [en ligne]. 7 juillet 2015. Vol. 31, n° 6pp. 660-666. [Consultésans date]. DOI 10.1051/medsci/20153106020. Consulté de : https://www.medecinesciences.org/fr/articles/medsci/abs/2015/07/medsci2015316-7p660/medsci2015316-7p660.html1. .
CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcript
TABET, R., SCHAEFFER, L., FREYERMUTH, F., JAMBEAU, M., WORKMAN, M., LEE, C. Z., LIN, C. C., JIANG, J., JANSEN-WEST, K., ABOU HAMDAN, Hussein, DESAUBRY, Laurent, GENDRON, T., PETRUCELLI, L., MARTIN, Franck et LAGIER-TOURENNE, C., 2018. CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcript. Nat Commun [en ligne]. 2018. Vol. 9, n° 1. [Consultésans date]. DOI 10.1038/s41467-017-02643-5. Consulté de : https://www.ncbi.nlm.nih.gov/pubmed/29323119?dopt=Abstract1. .
Deciphering of the mechanism of the anti-asthmatic action of the CXCL12 neutraligand, chalcone 4
DAUBEUF, Francois, BONNET, Dominique, BECKAERT, Virgile, OUADI, Ali, MARCHAND, Patrice, BRASSE, David, GIZZI, Patrick, HIBERT, Marcel, GALZI, Jean-Luc et FROSSARD, Nelly, 2014. Deciphering of the mechanism of the anti-asthmatic action of the CXCL12 neutraligand, chalcone 4. European Respiratory Journal [en ligne]. 2014. [Consultésans date]. Consulté de : http://erj.ersjournals.com/content/44/Suppl_58/34151. .
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors
KUMMERLE, A. E., SCHMITT, Martine, CARDOZO, S. V., LUGNIER, Claire, VILLA, Pascal, LOPES, A. B., ROMEIRO, N. C., JUSTINIANO, Hélène, MARTINS, M. A., FRAGA, C. A., BOURGUIGNON, Jean-Jacques J. et BARREIRO, E. J., 2012. Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors. Journal of Medicinal Chemistry [en ligne]. 14 août 2012. Vol. 55, n° 17pp. 7525-7545. [Consultésans date]. DOI 10.1021/jm300514y. Consulté de : https://pubs.acs.org/doi/10.1021/jm300514y1. .
Development of Dipeptidic hGPR54 Agonists.
DOEBELIN, Christelle, BERTIN, Isabelle, SCHNEIDER, Séverine, SCHMITT, Martine, BOURGUIGNON, Jean-Jacques, ANCEL, Caroline, SIMONNEAUX-EVE, Valerie, SIMONIN, Frédéric et BIHEL, Frederic, 2016. Development of Dipeptidic hGPR54 Agonists. ChemMedChem [en ligne]. 26 août 2016. Vol. 11, n° 19pp. 2147-2154. [Consulté 26 août 2016]. DOI 10.1002/cmdc.201600331. Consulté de : http://onlinelibrary.wiley.com/doi/10.1002/cmdc.201600331/abstract1. journal article. 2. 2016 Oct 06. 3. 2016 08 26. 4. . 5. imported. 6. .
Diastereoselective Synthesis of Novel Aza-diketopiperazines via a Domino Cyclohydrocarbonylation/Addition Process
REGENASS, Pierre-Michel, MARGATHE, Jean-François, MANN, Andre, SUFFERT, Jean, HIBERT, Marcel, GIRARD, Nicolas et BONNET, Dominique, 2014. Diastereoselective Synthesis of Novel Aza-diketopiperazines via a Domino Cyclohydrocarbonylation/Addition Process. Chemical Communications [en ligne]. 4 juillet 2014. [Consultésans date]. DOI 10.1039/C4CC03660C. Consulté de : http://pubs.rsc.org/en/content/articlehtml/2014/cc/c4cc03660c1. .
Discovery and characterization of an endogenous CXCR4 antagonist
ZIRAFI, O., KIM, K. A., STANDKER, L., MOHR, K. B., SAUTER, D., HEIGELE, A., KLUGE, S. F., WIERCINSKA, E., CHUDZIAK, D., RICHTER, R., MOEPPS, B., GIERSCHIK, P., VAS, V., GEIGER, H., LAMLA, M., WEIL, T., BURSTER, T., ZGRAJA, A., DAUBEUF, François, FROSSARD, Nelly, HACHET-HAAS, M., HEUNISCH, F., REICHETZEDER, C., GALZI, Jean-Luc L., PEREZ-CASTELLS, J., CANALES-MAYORDOMO, A., JIMENEZ-BARBERO, J., GIMENEZ-GALLEGO, G., SCHNEIDER, M., SHORTER, J., TELENTI, A., HOCHER, B., FORSSMANN, W. G., BONIG, H., KIRCHHOFF, F. et MUNCH, J., 2015. Discovery and characterization of an endogenous CXCR4 antagonist. Cell Reports [en ligne]. 23 avril 2015. Vol. 11, n° 5pp. 737-747. [Consultésans date]. DOI 10.1016/j.celrep.2015.03.061. Consulté de : http://www.sciencedirect.com/science/article/pii/S2211124715003526?via%3Dihub1. .
Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors
ELHABAZI, Khadija, HUMBERT, Jean-Paul ., BERTIN, Isabelle, SCHMITT, Martine, BIHEL, Frederic, BOURGUIGNON, Jean-Jacques ., BUCHER, Bernard, BECKER, Jerome A., SORG, Tania, MEZIANE, Hamid, PETIT-DEMOULIERE, BenoÎt, ILIEN, Brigitte et SIMONIN, Frédéric, 2013. Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors. Neuropharmacology [en ligne]. 1 août 2013. Vol. 75, pp. 164-171. [Consultésans date]. DOI 10.1016/j.neuropharm.2013.07.012. Consulté de : https://www.sciencedirect.com/science/article/pii/S0028390813003298?via%3Dihub1. .
Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1
ACHOUR, Mayada, MOUSLI, Marc, ALHOSIN, Mahmoud, IBRAHIM, Abdulkhaleg, PELUSO, Jean, MULLER, Christian D., SCHINI-KERTH, Valerie B., HAMICHE, Ali, DHE-PAGANON, Sirano et BRONNER, Christian, 2012. Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1. Biochemical and biophysical research communications [en ligne]. 28 novembre 2012. Vol. 430, n° 1pp. 208-212. [Consultésans date]. DOI 10.1016/j.bbrc.2012.11.087. Consulté de : https://www.sciencedirect.com/science/article/pii/S0006291X12022772?via%3Dihub1. .
Flavaglines as Potent Anticancer and Cytoprotective Agents
RIBEIRO, Nigel, THUAUD, Frédéric, BERNARD, Yohann, GAIDDON, Christian, CRESTEIL, T., HILD, A., HIRSCH, E. C., MICHEL, P. P., NEBIGIL, Canan G. et DESAUBRY, Laurent, 2012. Flavaglines as Potent Anticancer and Cytoprotective Agents. Journal of Medicinal Chemistry [en ligne]. 16 octobre 2012. Vol. 55, n° 22pp. 10064-10073. [Consultésans date]. DOI 10.1021/jm301201z. Consulté de : https://pubs.acs.org/doi/10.1021/jm301201z1. .
Fluorescent dyes and dye precursors
LELANT, Célia, BONNET, Dominique et GALZI, Jean-Luc, 2016. Fluorescent dyes and dye precursors. [en ligne]. 3 août 2016. [Consultésans date]. Consulté de : https://patents.google.com/patent/EP3050886A1/ar1. .
Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging
KARPENKO, Iuliia A., COLLOT, Mayeul, RICHERT, Ludovic, VALENCIA, Christel, VILLA, Pascal, MELY, Yves, HIBERT, Marcel, BONNET, Dominique et KLYMCHENKO, Andrey S., 2015. Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging. Journal of the American Chemical Society [en ligne]. 2015. Vol. 137, n° 1pp. 405-412. [Consultésans date]. DOI 10.1021/ja5111267. Consulté de : http://pubs.acs.org/doi/abs/10.1021/ja51112671. .
Inhibitors of the interaction between a protein belonging to GPRASP protein family and a protein belonging to GPCR protein family and their use as drugs
SIMONIN, Frédéric, FROSSARD, Nelly, DAUBEUF, Francois, ABU-HELO, A., BORNERT, O. et WAGNER, Renaud, 2012. Inhibitors of the interaction between a protein belonging to GPRASP protein family and a protein belonging to GPCR protein family and their use as drugs. . 2012. 1. Brevet retiré en 2013.
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments
ELHABAZI, Khadija, TRIGO, J. M., MOLLEREAU, C., MOULEDOUS, L., ZAJAC, J. M., BIHEL, Frédéric, SCHMITT, Martine, BOURGUIGNON, Jean-Jacques ., MEZIANE, Hamid, PETIT-DEMOULIERE, Benoït, BOCKEL, F., MALDONADO, R. et SIMONIN, Frédéric, 2011. Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments. British Journal of Pharmacology [en ligne]. 30 juin 2011. Vol. 165, n° 2pp. 424-435. [Consultésans date]. DOI 10.1111/j.1476-5381.2011.01563.x. Consulté de : https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1476-5381.2011.01563.x1. .
Isolation of novel stilbenoids from the roots of Cyrtopodium paniculatum (Orchidaceae)
AUBERON, Florence, OLATUNJI, Opeyemi Joshua, RAMINOSON, Diamondra, MULLER, Christian D., SOENGAS, Beatriz, BONTÉ, Frédéric et LOBSTEIN, Annelise, sans date. Isolation of novel stilbenoids from the roots of Cyrtopodium paniculatum (Orchidaceae). Fitoterapia. sans date. Vol. 116, pp. 99-105. DOI 10.1016/j.fitote.2016.11.015. 1. .
Les neutraligands à l'assaut des chimiokines
HACHET-HAAS, Muriel, DAUBEUF, François, HIBERT, Marcel, HAIECH, Jacques, FROSSARD, Nelly et GALZI, Jean-Luc, 2011. Les neutraligands à l'assaut des chimiokines. Biofutur. 2011. Vol. 319, pp. 52-55. 1. .

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