Plateforme de Chimie Biologique Intégrative de Strasbourg - PCBiS - UMS3286

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Acute Asthma Models to Ovalbumin in the Mouse
DAUBEUF, François et FROSSARD, N., 2013. Acute Asthma Models to Ovalbumin in the Mouse. Current protocols in mouse biology. 2013. Vol. 3, n° 1pp. 31-37. DOI 10.1002/9780470942390.mo120202.
The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma
REBER, L. L., DAUBEUF, François, NEMSKA, S. et FROSSARD, N., 2012. The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma. PLoS ONE. 2012. Vol. 7, n° 11. DOI 10.1371/journal.pone.0049512.
An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in mice
DAUBEUF, François, HACHET-HAAS, Muriel, GIZZI, Patrick, GASPARIK, Vincent, BONNET, Dominique, UTARD, Valérie, HIBERT, Marcel, FROSSARD, Nelly et GALZI, Jean-Luc ., 2013. An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in mice. Journal of Biological Chemistry [en ligne]. 28 février 2013. Vol. 288, n° 17pp. 11865-11876. [Consulté le : sans date]. DOI 10.1074/jbc.M112.449348. Consulté de : http://www.jbc.org/content/288/17/11865
Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaime (Psidium acutangulum Mart. ex DC., Myrtaceae)
HOUEL, E., FLEURY, M., ODONNE, G., NARDELLA, F., BOURDY, G., VONTHRON-SENECHEAU, C., VILLA, Pascal, OBRECHT, Adeline, EPARVIER, V., DEHARO, E. et STIEN, D., 2015. Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaime (Psidium acutangulum Mart. ex DC., Myrtaceae). Journal of Ethnopharmacology. 2015. Vol. 166, pp. 279-285. DOI 10.1016/j.jep.2015.03.015.
beta PIX-activated Rac1 stimulates the activation of phospholipase D, which is associated with exocytosis in neuroendocrine cells
MOMBOISSE, Fanny, LONCHAMP, Etienne, CALCO, Valerie, CERIDONO, Mara, VITALE, Nicolas, BADER, Marie-france et GASMAN, Stephane, 2009. beta PIX-activated Rac1 stimulates the activation of phospholipase D, which is associated with exocytosis in neuroendocrine cells. Journal of Cell Science. 2009. Vol. 122, n° 6pp. 798-806. DOI 10.1242/jcs.038109.
Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells
ZENIOU, M., FEVE, M., MAMERI, S., DONG, J., SALOME, C., CHEN, W., EL-HABR, E. A., BOUSSON, F., SY, M., OBSZYNSKI, J., BOH, A., VILLA, Pascal, ASSAD KAHN, S., DIDIER, Bruno, BAGNARD, D., JUNIER, M. P., CHNEIWEISS, H., HAIECH, J., HIBERT, M. et KILHOFFER, M. C., 2015. Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells. PLoS ONE. 2015. Vol. 10, n° 8. DOI 10.1371/journal.pone.0134793.
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody
MAILLY, Laurent, XIAO, Fei, LUPBERGER, Joachim, WILSON, G. K., AUBERT, P., DUONG, F. H., CALABRESE, D., LEBOEUF, Céline, FOFANA, Isabel, THUMANN, Christine, BANDIERA, Simonetta, LUTGEHETMANN, M., VOLZ, T., DAVIS, C., HARRIS, H. J., MEE, C. J., GIRARDI, Erika, CHANE-WOON-MING, Béatrice, ERICSSON, M., FLETCHER, N., BARTENSCHLAGER, R., PESSAUX, Patrick, VERCAUTEREN, K., MEULEMAN, P., VILLA, Pascal, KADERALI, L., PFEFFER, Sebastien, HEIM, M. H., NEUNLIST, M., ZEISEL, Mirjam B., DANDRI, M., MACKEATING, J. A., ROBINET, Eric et BAUMERT, Thomas F., 2015. Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody. Nature Biotechnology [en ligne]. 23 mars 2015. Vol. 33, n° 5pp. 549-554. [Consulté le : sans date]. DOI 10.1038/nbt.3179. Consulté de : https://www.nature.com/articles/nbt.3179
Contrôle qualité des chimiothèques. [= Quality control of chemical libraries]
GALZI, Jean-Luc ., RUGGIU, Fiorella, GIZZI, Patrick et DIDIER, Bruno, 2015. Contrôle qualité des chimiothèques. [= Quality control of chemical libraries]. médecine/sciences [en ligne]. 7 juillet 2015. Vol. 31, n° 6pp. 660-666. [Consulté le : sans date]. DOI 10.1051/medsci/20153106020. Consulté de : https://www.medecinesciences.org/fr/articles/medsci/abs/2015/07/medsci2015316-7p660/medsci2015316-7p660.html
Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model
BOLLENBACH, Maud, NEMSKA, Simona, WAGNER, Patrick, CAMELIN, Guillaume, DAUBEUF, François, OBRECHT, Adeline, VILLA, Pascal, ROGNAN, Didier, BIHEL, Frédéric, BOURGUIGNON, Jean-Jacques, SCHMITT, Martine et FROSSARD, Nelly, 2021. Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model. Molecules [en ligne]. 2021. [Consulté le : sans date]. DOI 10.3390/molecules26020391. Consulté de : https://www.mdpi.com/1420-3049/26/2/391
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors
KUMMERLE, A. E., SCHMITT, Martine, CARDOZO, S. V., LUGNIER, Claire, VILLA, Pascal, LOPES, A. B., ROMEIRO, N. C., JUSTINIANO, Hélène, MARTINS, M. A., FRAGA, C. A., BOURGUIGNON, Jean-Jacques J. et BARREIRO, E. J., 2012. Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors. Journal of Medicinal Chemistry [en ligne]. 14 août 2012. Vol. 55, n° 17pp. 7525-7545. [Consulté le : sans date]. DOI 10.1021/jm300514y. Consulté de : https://pubs.acs.org/doi/10.1021/jm300514y
Diastereoselective Synthesis of Nonplanar 3-Amino-1,2,4-oxadiazine Scaffold: Structure Revision of Alchornedine
TANG, Shuang-qi, LELOIRE, Maeva, SCHNEIDER, Severine, MOHR, Julie, BRICARD, Jacques, GIZZI, Patrick, GARNIER, Delphine, SCHMITT, Martine et BIHEL, Frederic, 2020. Diastereoselective Synthesis of Nonplanar 3-Amino-1,2,4-oxadiazine Scaffold: Structure Revision of Alchornedine. The Journal of Organic Chemistry. 4 décembre 2020. Vol. 85, n° 23pp. 15347-15359. DOI 10.1021/acs.joc.0c01764.
Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue
BECK, I. M., VAN CROMBRUGGEN, K., HOLTAPPELS, G., DAUBEUF, François, FROSSARD, N., BACHERT, C. et DE BOSSCHER, K., 2015. Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue. PLoS ONE. 2015. Vol. 10, n° 4. DOI 10.1371/journal.pone.0123068.
Discovery and characterization of an endogenous CXCR4 antagonist
ZIRAFI, O., KIM, K. A., STANDKER, L., MOHR, K. B., SAUTER, D., HEIGELE, A., KLUGE, S. F., WIERCINSKA, E., CHUDZIAK, D., RICHTER, R., MOEPPS, B., GIERSCHIK, P., VAS, V., GEIGER, H., LAMLA, M., WEIL, T., BURSTER, T., ZGRAJA, A., DAUBEUF, François, FROSSARD, Nelly, HACHET-HAAS, M., HEUNISCH, F., REICHETZEDER, C., GALZI, Jean-Luc L., PEREZ-CASTELLS, J., CANALES-MAYORDOMO, A., JIMENEZ-BARBERO, J., GIMENEZ-GALLEGO, G., SCHNEIDER, M., SHORTER, J., TELENTI, A., HOCHER, B., FORSSMANN, W. G., BONIG, H., KIRCHHOFF, F. et MUNCH, J., 2015. Discovery and characterization of an endogenous CXCR4 antagonist. Cell Reports [en ligne]. 23 avril 2015. Vol. 11, n° 5pp. 737-747. [Consulté le : sans date]. DOI 10.1016/j.celrep.2015.03.061. Consulté de : http://www.sciencedirect.com/science/article/pii/S2211124715003526?via%3Dihub
A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma
REBER, L. L., DAUBEUF, François, PLANTINGA, M., DE CAUWER, L., GERLO, S., WAELPUT, W., VAN CALENBERGH, S., TAVERNIER, J., HAEGEMAN, G., LAMBRECHT, B. N., FROSSARD, N. et DE BOSSCHER, K., 2012. A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma. Journal of Immunology [en ligne]. 5 mars 2012. Vol. 188, n° 7pp. 3478-3487. [Consulté le : sans date]. DOI 10.4049/jimmunol.1004227. Consulté de : http://www.jimmunol.org/content/188/7/3478
Do iodinated nano-emulsions designed for preclinical vascular imaging alter the vascular reactivity in rat aorta?
ANTON, Nicolas, ATZENHOFFER, Marina, DAUBEUF, Francois, LI, Xiang, SCHINI-KERTH, Valerie B., DELMOTTE, Barbara, VANDAMME, Thierry F. et CHATAIGNEAU, Thierry, 2013. Do iodinated nano-emulsions designed for preclinical vascular imaging alter the vascular reactivity in rat aorta? International Journal of Pharmaceutics [en ligne]. 10 juillet 2013. Vol. 454, n° 1pp. 143-148. [Consulté le : sans date]. DOI 10.1016/j.ijpharm.2013.07.007. Consulté de : https://www.sciencedirect.com/science/article/pii/S037851731300611X?via%3Dihub
Eosinophils and the ovalbumin mouse model of asthma
DAUBEUF, François et FROSSARD, N., 2014. Eosinophils and the ovalbumin mouse model of asthma. Methods in Molecular Biology. 2014. Vol. 1178, pp. 283-293. DOI 10.1007/978-1-4939-1016-8_24.
Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging
KARPENKO, Iuliia A., COLLOT, Mayeul, RICHERT, Ludovic, VALENCIA, Christel, VILLA, Pascal, MELY, Yves, HIBERT, Marcel, BONNET, Dominique et KLYMCHENKO, Andrey S., 2015. Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging. Journal of the American Chemical Society [en ligne]. 2015. Vol. 137, n° 1pp. 405-412. [Consulté le : sans date]. DOI 10.1021/ja5111267. Consulté de : http://pubs.acs.org/doi/abs/10.1021/ja5111267
Full-root aortic valve replacement with stentless xenograft achieves superior regression of left ventricular hypertrophy compared to pericardial stented aortic valves
TAVAKOLI, R., AUF DER MAUR, C., MUELLER, X., SCHLAPFER, R., JAMSHIDI, P., DAUBEUF, François et FROSSARD, N., 2015. Full-root aortic valve replacement with stentless xenograft achieves superior regression of left ventricular hypertrophy compared to pericardial stented aortic valves. Journal of Cardiothoracic Surgery. 2015. Vol. 10. DOI 10.1186/s13019-015-0219-8.
A general framework to characterize inhibitors of calmodulin: use of calmodulin inhibitors to study the interaction between calmodulin and its calmodulin binding domains
AUDRAN, E., DAGHER, R., GIORIA, Sophie, TSVETKOV, P. O., KULIKOVA, A. A., DIDIER, Bruno, VILLA, Pascal, MAKAROV, A. A., KILHOFFER, M. C. et HAIECH, J., 2013. A general framework to characterize inhibitors of calmodulin: use of calmodulin inhibitors to study the interaction between calmodulin and its calmodulin binding domains. BBA - Biochimica et Biophysica Acta. 2013. Vol. 1833, n° 7pp. 1720-1731. DOI 10.1016/j.bbamcr.2013.01.008.
A general strategy to characterize calmodulin-calcium complexes involved in CaM-target recognition: DAPK and EGFR calmodulin binding domains interact with different calmodulin-calcium complexes
DAGHER, R., PENG, S., GIORIA, Sophie, FEVE, M., ZENIOU, M., ZIMMERMANN, M., PIGAULT, C., HAIECH, J. et KILHOFFER, M. C., 2011. A general strategy to characterize calmodulin-calcium complexes involved in CaM-target recognition: DAPK and EGFR calmodulin binding domains interact with different calmodulin-calcium complexes. BBA - Biochimica et Biophysica Acta. 2011. Vol. 1813, n° 5pp. 1059-1067. DOI 10.1016/j.bbamcr.2010.11.004.

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