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PDE inhibitors: a new approach to treat metabolic syndrome?

PDE inhibitors: a new approach to treat metabolic syndrome?: Pas de texte intégral; Lugnier Claire; Articles Scientifiques; 2011; Current opinion in pharmacology; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments: Pas de texte intégral; Keravis T, Lugnier Claire; Articles Scientifiques; 2012; British Journal of Pharmacology; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-kappaB signalling pathways while reducing proinflammatory cytokine production

NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-kappaB signalling pathways while reducing proinflammatory cytokine production: Pas de texte intégral; Yougbare I, Boire G, Roy M, Lugnier Claire, Rouseau E; Articles Scientifiques; 2013; Canadian Journal of Physiology and Pharmacology; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1

Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1: Pas de texte intégral; Abusnina A, Keravis T, Yougbare I, Bronner C, Lugnier Claire; Articles Scientifiques; 2011; Molecular Nutrition and Food Research; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues

NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues: Pas de texte intégral; Yougbare I, Morin C, Senouvo F, Sirois C, Albadine R, Lugnier Claire, Rousseau E; Articles Scientifiques; 2011; AJP - Lung Cellular and Molecular Physiology; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition

Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition: Pas de texte intégral; Abusnina A, Keravis T, Zhou Q, Justiniano Hélène, Lobstein A, Lugnier Claire; Articles Scientifiques; 2015; Thrombosis and Haemostasis; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213, Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

Tissue and substrate specificity of inhibition by alkoxy-aryl-lactams of platelet and arterial smooth muscle cyclic nucleotide phosphodiesterases relationship to pharmacological activity.

Tissue and substrate specificity of inhibition by alkoxy-aryl-lactams of platelet and arterial smooth muscle cyclic nucleotide phosphodiesterases relationship to pharmacological activity.: Pas de texte intégral; Lugnier Claire, Stierlé A, Beretz Alain, Schoeffter P, Lebec A, Wermuth CG, Cazenave Jean-pierre, Stoclet JC; Articles Scientifiques; 1983-06; Biochemical and Biophysical Research Communications; Université de Strasbourg - UNISTRA - UNISTRA, Université de Strasbourg - UNISTRA - UNISTRA, Institut de Génétique et de Biologie Moléculaire et Cellulaire - IGBMC - UMR7104, Université de Strasbourg - UNISTRA - UNISTRA

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis: Pas de texte intégral; Abusnina A, Alhosin M, Keravis T, Muller C, Fuhrmann Guy, Bronner C, Lugnier Claire; Articles Scientifiques; 2011; Cellular signalling; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213, Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

Triazolo[4,3-a]quinoline and tetrazolo[1,5-a]quinoline derivatives. Synthesis and pharmacological evaluation as platelets antiaggregating agents acting through phosphodiesterases inhibition,Dérivés de triazolo[4,3-a]quinoléines et de tétrazolo[1,5-a]quino

Triazolo[4,3-a]quinoline and tetrazolo[1,5-a]quinoline derivatives. Synthesis and pharmacological evaluation as platelets antiaggregating agents acting through phosphodiesterases inhibition,Dérivés de triazolo[4,3-a]quinoléines et de tétrazolo[1,5-a]quinoléines synthèse, évaluation pharmacologique en tant qu'agents antiagrégants plaquettaires agissant par inhibition de phosphodiestérases: Pas de texte intégral; Desos P., Schlewer Gilbert, Lugnier Claire, Beretz Alain, Maffrand J., Bernat A., Wermuth C.; Articles Scientifiques; 1991; European Journal of Medicinal Chemistry; Laboratoire d'Innovation Thérapeutique - LIT - UMR7200, Mitochondrie, Stress oxydant et Protection musculaire - MSP - UR3072, Université de Strasbourg - UNISTRA - UNISTRA

Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation

Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation: Pas de texte intégral; Kolli-Bouhafs K, Boukhari A, Abusnina A, Velot E, Gies Jean-Pierre, Lugnier Claire, Ronde Philippe; Articles Scientifiques; 2012; Investigational New Drugs; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213, Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213, Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

$Endothelium-independent and endothelium-dependent vasorelaxation by a dichloromethane fraction from Anogeissus Leiocarpus (DC) Guill. Et Perr. (Combretaceae): possible involvement of cyclic nucleotide phosphodiesterase inhibition$

Endothelium-independent and endothelium-dependent vasorelaxation by a dichloromethane fraction from Anogeissus Leiocarpus (DC) Guill. Et Perr. (Combretaceae): possible involvement of cyclic nucleotide phosphodiesterase inhibition: Pas de texte intégral; Belemnaba L, Ouedraogo S, Auger Cyril, Chataigneau T, Traore A, Guissou I, Lugnier Claire, Schini-Kerth Valérie, Bucher B; Articles Scientifiques; 2013; African journal of traditional, complementary, and alternative medicines; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213, Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213, Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling

Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling: Pas de texte intégral; Yougbare I, Keravis T, Abusnina A, Decossas M, Schall N, Muller S, Lugnier Claire; Articles Scientifiques; 2014; BBA - Biochimica et Biophysica Acta; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam

New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam: Pas de texte intégral; Bihel F, Justiniano Hélène, Schmitt M, Hellal M, Ibrahim M, Lugnier Claire, Bourguignon J; Articles Scientifiques; 2011; Bioorganic and medicinal chemistry letters; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213, Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4 (PDE4) Inhibitor

Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4 (PDE4) Inhibitor: Accès libre Peer reviewed; Keravis T, Monneaux F, Yougbare I, Gazi L, Bourguignon J, Muller S, Lugnier Claire; Articles Scientifiques; 2012; PLoS One; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells

Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells: Accès libre Peer reviewed; Keravis T, Favot L, Abusnina A, Anton A, Justiniano Hélène, Soleti R, Alabed Alibrahim E, Simard G, Andriantsitohaina R, Lugnier Claire; Articles Scientifiques; 2015; PLoS ONE; Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213, Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213

Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors

Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors: Accès restreint (Indéfini) Peer reviewed; Kummerle A, Schmitt Martine, Cardozo S, Lugnier Claire, Villa Pascal, Lopes A, Romeiro N, Justiniano Hélène, Martins M, Fraga C, Bourguignon Jean-Jacques, Barreiro E; Articles Scientifiques; 2012-08-14; Journal of Medicinal Chemistry; Laboratoire d'Innovation Thérapeutique - LIT - UMR7200, Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213, Plateforme de Chimie Biologique Intégrative de Strasbourg - PCBiS - UMS3286, Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213, Laboratoire d'Innovation Thérapeutique - LIT - UMR7200

Angiotensin-converting enzyme inhibition prevents myocardial infarction-induced increase in renal cortical cGMP and cAMP phosphodiesterase activities

Angiotensin-converting enzyme inhibition prevents myocardial infarction-induced increase in renal cortical cGMP and cAMP phosphodiesterase activities: Pas de texte intégral; Clauss F, Charloux Anne, Piquard Francois, Doutreleau S, Talha Samy, Zoll Joffrey, Lugnier Claire, Geny Bernard; Articles Scientifiques; 2015; Fundamental and Clinical Pharmacology; Mitochondrie, Stress oxydant et Protection musculaire - MSP - EA3072, Mitochondrie, Stress oxydant et Protection musculaire - MSP - EA3072, Mitochondrie, Stress oxydant et Protection musculaire - MSP - EA3072, Mitochondrie, Stress oxydant et Protection musculaire - MSP - EA3072, Laboratoire de Biophotonique et Pharmacologie - LBP - UMR7213, Mitochondrie, Stress oxydant et Protection musculaire - MSP - EA3072

Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model

Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model: Pas de texte intégral; Bollenbach Maud, Lugnier Claire, Kremer Mélanie, Salvat Eric, Megat Salim, Bihel Frederic, Bourguignon Jean-jacques, Barrot Michel, Schmitt Martine; Articles Scientifiques; 2019-09; European Journal of Medicinal Chemistry; Laboratoire d'Innovation Thérapeutique - LIT - UMR7200, Mitochondrie, Stress oxydant et Protection musculaire - MSP - EA3072, Institut des Neurosciences Cellulaires et Intégratives - INCI - UPR3212, Institut des Neurosciences Cellulaires et Intégratives - INCI - UPR3212, Mécanismes centraux et périphériques de la neurodégénérescence - MCPN - UMRS1118, Laboratoire d'Innovation Thérapeutique - LIT - UMR7200, Laboratoire d'Innovation Thérapeutique - LIT - UMR7200, Institut des Neurosciences Cellulaires et Intégratives - INCI - UPR3212, Laboratoire d'Innovation Thérapeutique - LIT - UMR7200

Endothelium-independent vasorelaxant effect of a Berberis orthobotrys root extract via inhibition of phosphodiesterases in the poricine coronary artery

Endothelium-independent vasorelaxant effect of a Berberis orthobotrys root extract via inhibition of phosphodiesterases in the poricine coronary artery: Accès restreint (Indéfini) Peer reviewed; Alamgeer P, Chabert P, Akhtar M S, Jabeen Q, Delecolle Julien, Heintz Dimitri, Garo E, Hamburger M, Auger Cyril, Lugnier Claire, Kim H J, Oak M H, Schini-kerth Valerie; Articles Scientifiques; 2016; Phytomedicine; Institut de Biologie Moléculaire des Plantes - IBMP - UPR2357, Institut de Biologie Moléculaire des Plantes - IBMP - UPR2357, Nanomédecine Régénérative - NanoRegMed - UMRS1260, Mitochondrie, Stress oxydant et Protection musculaire - MSP - EA3072, Nanomédecine Régénérative - NanoRegMed - UMRS1260

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